Industrial Chemistry and Water Treatment

Lead Drug Discovery

A lead compound is usually defined as a latest chemical entity that could potentially be developed into a latest drug by optimizing its beneficial effects and minimizing its side effects. The method by which a drug is delivered can have a crucial effect on its efficacy. Attempts are being made to develop, granulocyte colony-stimulating factor, interferon-alpha, and antibodies, due to problems with fundamental technologies for protein drug discovery. Liquid dispersions & additionally nanoparticle dispersions consisting of small particles of 10–400 nm diameter show great promise as drug delivery systems. Lead discovery includes -

• Choosing disease and drug target.
• Identifying a bioassay.
• Finding a lead compound.
• Isolation and purification.
• Structure determination
• SAR(Structure Activity Relationship)
• Identification of pharmacophore.