Lead Drug Discovery

The method by which a drug is delivered can have a significant effect on its efficacy. To minimize drug degradation and loss, to prevent harmful side-effects and to increase drug bioavailability and the fraction of the drug accumulated in the required zone, various drug delivery and drug targeting systems are currently under development. Attempts are being made to develop therapeutic proteins for cancer, hepatitis, and autoimmune conditions, but their clinical applications are limited, except in the cases of drugs based on erythropoietin, granulocyte colony-stimulating factor, interferon-alpha, and antibodies, owing to problems with fundamental technologies for protein drug discovery. Technologies profiled include those used for biomarker and target discovery such as high throughput screening, signal transduction, micro array, RNAi, metabolomics, toxicogenomics, biosensors and nanotechnology. Colloidal drug carrier systems such as micelle solutions, vesicle and liquid crystal dispersions, as well as nanoparticle dispersions consisting of small particles of 10–400 nm diameter show great promise as drug delivery systems. Lead discovery includes -
1.Choosing disease and drug target.
2. Identifying a bioassay.
3. Finding a lead compound.
4. Isolation and purification.
5. Structure determination
6.SAR
7.Identification of pharmacophore.

 

  • Choosing Disease and Drug Target
  • Identification of Pharmacophore
  • Lead Compounds and SAR
  • High throughput screening
  • Computer-aided drug design

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