Industrial Chemistry

Biography

Biography: Radhey Srivastava

Abstract

The central importance of organonitrogen compounds, especially amine derivatives, as both synthetic intermediates and useful end-products provides a powerful incentive to develop efficient, selective, and sustainable methods for the formation of C-N bonds from abundant feedstocks. The growing ability of transition metal compounds to activate and transform C-H and C-C bonds of hydrocarbons offers new opportunities for the development of metal catalyzed C-N bond-forming reactions. The discovery and development of new, synthetically useful metal-catalyzed hydrocarbon nitrogenation reactions will be greatly facilitated by elucidating the reactivity of organonitrogen-metal complexes toward unsaturated and saturated hydrocarbons. The Chiral version of amines is a powerful pharmacophores for defining new pharmaceutical drugs but perhaps this is not surprising due to their high density of structural information which is augmented by their propensity for hydrogen bond formation. Transition metal-catalyzed asymmetric allylic amination (AAA) have been reported. Among those Pd- and Ir-catalytic methods found to be the most common using mainly pre-functionalized olefins such as allyl halides and allyl acetates (nucleophilic allylic substitutions) and simple olefins (allylic C-H amination). These methods though find practical applications in the synthetic chemistry, most of them suffer due to the requirement of olefin pre-functionalization and byproducts such as salts. In order to overcome the existing limitations, the more economical and useful catalytic allylic C-H amination of simple olefins is required. Recently we have made progress in developing copper-catalyzed asymmetric allyl amination of alkenes using aryl hydroxylamine as nitrogen fragment donors, which has not been reported so far. The result of this study will form the subject matter of the present talk.